Engineers build "smart" pills for drug delivery
Three-dimensional patterning allow for a wider range of functions in the targeted device. It also creates a greater surface area to volume ratio in the device, which allows for better control of drug delivery.
The Hopkins group developed a way to use lithography to create three-dimensional circuitry. First, a three-dimensional structure is planned out on a two-dimensional template that is interconnected by a set of hinges. Once this complex is activated, the hinges cause the template to fold into a three-dimensional structure.
In many ways, this is similar to drawing a template for origami or a paper airplane onto a sheet of paper before folding it up. The pattern is already there, in two dimensions; folding "activates" the pattern and transforms it into a useful, three-dimensional object.
The Hopkins group applied this technique to the development of drug delivery devices. By creating a two-dimensional template for their device, they were able to design a capsule that targets drug delivery in controllable ways. Their device, once it reaches the market, could have wide uses in medical care.
One important feature of the new product is its flexible design, which allows it to change shape and size to pass through various tissues. A gold coating creates a smooth surface that should minimize attacks by the immune system. Additionally, the metal coat allows the capsule to be detected by MRI, allowing doctors to follow the delivery of the drug in real time.
Further studies are needed before this product can be tested in humans and used to delivery drugs in a clinical setting, but this new approach seems to have a variety of advantages over traditional drug delivery systems. "Smart" delivery of medicines within the body may soon be a reality.
The Hopkins group developed a way to use lithography to create three-dimensional circuitry. First, a three-dimensional structure is planned out on a two-dimensional template that is interconnected by a set of hinges. Once this complex is activated, the hinges cause the template to fold into a three-dimensional structure.
In many ways, this is similar to drawing a template for origami or a paper airplane onto a sheet of paper before folding it up. The pattern is already there, in two dimensions; folding "activates" the pattern and transforms it into a useful, three-dimensional object.
The Hopkins group applied this technique to the development of drug delivery devices. By creating a two-dimensional template for their device, they were able to design a capsule that targets drug delivery in controllable ways. Their device, once it reaches the market, could have wide uses in medical care.
One important feature of the new product is its flexible design, which allows it to change shape and size to pass through various tissues. A gold coating creates a smooth surface that should minimize attacks by the immune system. Additionally, the metal coat allows the capsule to be detected by MRI, allowing doctors to follow the delivery of the drug in real time.
Further studies are needed before this product can be tested in humans and used to delivery drugs in a clinical setting, but this new approach seems to have a variety of advantages over traditional drug delivery systems. "Smart" delivery of medicines within the body may soon be a reality.
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